Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 18/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 9/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3124522 | 1.00 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL3122399 | 0.95 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL3132694 | 0.94 | REN (0.96) | RENKCNH2CYP3A4 | |
| SCHEMBL3122463 | 0.92 | REN (0.91) | RENKCNH2CYP3A4 | |
| SCHEMBL3251287 | 0.92 | REN (0.91) | RENKCNH2CYP3A4 | |
| SCHEMBL13268192 | 0.92 | REN (0.91) | RENKCNH2CYP3A4 | |
| SCHEMBL3034460 | 0.92 | REN (0.91) | RENKCNH2CYP3A4 | |
| SCHEMBL8163856 | 0.92 | REN (0.90) | RENKCNH2CYP3A4 | |
| SCHEMBL3124429 | 0.92 | REN (0.93) | RENKCNH2CYP3A4 | |
| SCHEMBL3126938 | 0.91 | REN (0.91) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097377-B1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2010-07-07 | — | — | EP | disclosed |