Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3259962 | 0.86 | JAK2 (0.52) | JAK2JAK3PTK2JAK1L3MBTL1 | |
| SCHEMBL17886514 | 0.85 | JAK2 (0.53) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL2775371 | 0.81 | MAPK1 (0.50) | AHRLMNAL3MBTL1 | |
| SCHEMBL18202882 | 0.81 | KDM4E (0.48) | AHRJAK2JAK3PTK2LMNA | |
| SCHEMBL13535387 | 0.80 | JAK1 (0.58) | JAK2JAK3LMNAJAK1 | |
| SCHEMBL13535757 | 0.79 | AHR (0.50) | MAP4K4LRRK2AHRJAK2JAK3 | |
| SCHEMBL3263162 | 0.78 | JAK2 (0.53) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL30496382 | 0.75 | JAK2 (0.55) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL13535843 | 0.73 | JAK2 (0.62) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL1691501 | 0.73 | JAK2 (0.56) | JAK2JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010186-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010186-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |