Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.53 |
| ▸ | JAK3 | P52333 | 8/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13535843 | 0.88 | JAK2 (0.62) | JAK2JAK3PTK2NPC1RAB9A | |
| SCHEMBL3262742 | 0.88 | JAK2 (0.54) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL1691501 | 0.88 | JAK2 (0.56) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3259962 | 0.87 | JAK2 (0.52) | JAK2JAK3PTK2MAPTJAK1 | |
| SCHEMBL13535688 | 0.85 | JAK2 (0.50) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL16554085 | 0.83 | RAB9A (0.55) | JAK2JAK3PTK2NPC1RAB9A | |
| SCHEMBL3261610 | 0.81 | JAK1 (0.53) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535582 | 0.80 | JAK1 (0.50) | JAK2JAK1 | |
| SCHEMBL3262458 | 0.80 | JAK2 (0.51) | JAK2JAK3PTK2 | |
| SCHEMBL13535593 | 0.80 | JAK2 (0.77) | JAK2JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |