Histidine

Histidine

SCHEMBL3260

N[C@@H](Cc1cnc[nH]1)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 1.00
SLC7A5 Q01650 1/20 1.00
CPB2 Q96IY4 1/20 0.59
ALDH1A1 P00352 4/20 0.58
HRH4 Q9H3N8 3/20 0.58
HRH3 Q9Y5N1 3/20 0.58
NFKB1 P19838 2/20 0.58
MEN1 O00255 1/20 0.58
GLA P06280 1/20 0.58
KMT2A Q03164 1/20 0.58
CYP1A2 P05177 1/20 0.58
THPO P40225 1/20 0.58
LMNA P02545 1/20 0.56
APEX1 P27695 1/20 0.56
BLM P54132 1/20 0.56
GABRA1 P14867 1/20 0.55
TSHR P16473 1/20 0.55
GABRR1 P24046 1/20 0.55
GABRR2 P28476 1/20 0.55
GABRA5 P31644 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL28071764 1.00 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL30852263 1.00 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL137600 1.00 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL388560 1.00 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
D-Histidine SCHEMBL288043 1.00 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL19974306 1.00 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL25357958 0.98 CYP3A4 (0.97) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL25267810 0.98 CYP3A4 (0.97) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL6005501 0.98 CYP3A4 (0.97) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL25362582 0.98 CYP3A4 (0.97) CYP3A4SLC7A5CPB2ALDH1A1HRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 720510 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9974833-B2 Methods of using compositions comprising variants and fusions of FGF19 polypeptides for modulating bile acid homeostasis in a subject having pregnancy intrahepatic cholestasis NGM BIOPHARMACEUTICALS, INC. (US) 2018-05-22 US claimed
US-9976076-B2 Photochromic articles containing a polyoxometalate and methods of making same 3M INNOVATIVE PROPERTIES COMPANY (US) 2018-05-22 US claimed
US-9974851-B2 Human rotavirus vaccine strains and diagnostics THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2018-05-22 US claimed
US-9976126-B2 Modified glycine oxidase AJINOMOTO CO., INC. (JP) 2018-05-22 US claimed
US-9976184-B2 Mutations in pancreatic neoplasms THE JOHNS HOPKINS UNIVERSITY (US) 2018-05-22 US claimed
US-9976077-B2 Photochromic articles containing polyoxometalate derivatives and methods of making same 3M INNOVATIVE PROPERTIES COMPANY (US) 2018-05-22 US claimed
US-9976074-B2 Self-suspending proppant particulates using canola protein-based hydrogel HALLIBURTON ENERGY SERVICES, INC. (US) 2018-05-22 US claimed
US-20180136227-A1 Treatment and Diagnosis of Hereditary Xerocytosis CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2018-05-17 US claimed
US-20180134988-A1 PROCESS FOR REMOVING METAL FROM A METAL-CONTAINING GLYCERIDE OIL COMPRISING A BASIC QUATERNARY AMMONIUM SALT TREATMENT EVONIK DEGUSSA GMBH (DE) 2018-05-17 US claimed
US-20180135086-A1 MICROORGANISM PRODUCING O-ACETYL-HOMOSERINE, AND METHOD FOR PRODUCING O-ACETYL-HOMOSERINE BY USING SAME CJ CHEILJEDANG CORPORATION (KR) 2018-05-17 US claimed
US-3991107-A Haloamine transfer NATIONAL PATENT DEVELOPMENT CORPORATION (US) 1976-11-09 US claimed
US-3988466-A ANTIINFLAMMATORY, AMINO ACIDS KYOWA HAKKO KOGYO CO., LTD. (JA) 1976-10-26 US claimed
US-3988307-A ATTACHING AN ALPHA,BETA-UNSATURATED AMINO ACID TO A SOLID SUPPORT; ACIDIC AQUEOUS RELEASE AGENT THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) 1976-10-26 US claimed
US-3973574-A Waving and straightening hair by producing metal chelates in the keratin of the hair Umezawa, Fumio (JA) 1976-08-10 US claimed
US-3971737-A [2-Methyl-Ala6 ]LRH AMERICAN HOME PRODUCTS CORPORATION (US) 1976-07-27 US claimed
US-3963691-A POLYPEPTIDES, PEPTIZATION MERCK & CO., INC. (US) 1976-06-15 US claimed
US-3959248-A TRIPEPTIDES; ANTIDEPRESSANTS MERCK & CO., INC. (US) 1976-05-25 US claimed
US-3953416-A Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same FOLKERS KARL 1976-04-27 US claimed
US-3950513-A NONTOXIC AMINO ACID NOVO TERAPEUTISK LABORATORIUM A/S (DK) 1976-04-13 US claimed
US-3943038-A Method for producing amino acids by culturing hydrogen-oxidizing bacteria AJINOMOTO CO., INC. (JA) 1976-03-09 US claimed