Histidine

Histidine

SCHEMBL137600

NC(Cc1cnc[nH]1)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 1.00
SLC7A5 Q01650 1/20 1.00
CPB2 Q96IY4 1/20 0.59
ALDH1A1 P00352 4/20 0.58
HRH4 Q9H3N8 3/20 0.58
HRH3 Q9Y5N1 3/20 0.58
NFKB1 P19838 2/20 0.58
MEN1 O00255 1/20 0.58
GLA P06280 1/20 0.58
KMT2A Q03164 1/20 0.58
CYP1A2 P05177 1/20 0.58
THPO P40225 1/20 0.58
LMNA P02545 1/20 0.56
APEX1 P27695 1/20 0.56
BLM P54132 1/20 0.56
GABRA1 P14867 1/20 0.55
TSHR P16473 1/20 0.55
GABRR1 P24046 1/20 0.55
GABRR2 P28476 1/20 0.55
GABRA5 P31644 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL28071764 1.00 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL30852263 1.00 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL3260 1.00 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL388560 1.00 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
D-Histidine SCHEMBL288043 1.00 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL19974306 1.00 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL25357958 0.98 CYP3A4 (0.97) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL25267810 0.98 CYP3A4 (0.97) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL6005501 0.98 CYP3A4 (0.97) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL25362582 0.98 CYP3A4 (0.97) CYP3A4SLC7A5CPB2ALDH1A1HRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 828 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122094997-A Aqueous polyurethane coatings for printing applications 2026-05-26 CN claimed
WO-2025088050-A1 WATERBORNE POLYURETHANE COATING FOR PRINTING APPLICATIONS COVESTRO DEUTSCHLAND AG (DE) 2025-05-01 WO claimed
CN-119431814-A Histidine piezoelectric material constructed through chiral strategy and preparation method and application thereof 新疆农业大学 2025-02-14 CN claimed
CN-119156099-A Perovskite solution, perovskite film, preparation method of perovskite solution and perovskite film, and photovoltaic device 仁烁光能(苏州)有限公司 2024-12-17 CN claimed
EP-3873955-B1 AMINO ACID GRAFTED POLYMER WITH SOOT HANDLING PROPERTIES AFTON CHEMICAL CORP (US) 2024-12-04 EP claimed
CN-118406439-B Chemical mechanical polishing composition and application thereof in tungsten chemical mechanical polishing 万华化学集团电子材料有限公司 2024-10-18 CN claimed
CN-118406439-A Chemical mechanical polishing composition and application thereof in tungsten chemical mechanical polishing 万华化学集团电子材料有限公司 2024-07-30 CN claimed
CN-117512057-A Composition, kit and method for glutathione reductase detection and calibration 湖北擎科生物科技有限公司 2024-02-06 CN claimed
CN-116918859-A Anti-biofilm carbon dot-based nano-enzyme and preparation method and application thereof 渤海大学 2023-10-24 CN claimed
CN-110707221-B Application of amino acid ionic liquid in preparation of perovskite layer in perovskite photoelectric device 北京大学深圳研究生院 2023-09-01 CN claimed
US-20020010154-A1 Compositions comprising cyclodextrin THE PROCTER & GAMBLE COMPANY 2002-01-24 US claimed
WO-2001088076-A1 COMPOSITIONS COMPRISING CYCLODEXTRIN THE PROCTER & GAMBLE COMPANY (US) 2001-11-22 WO claimed
US-6289286-B1 Surface regeneration of biosensors and characterization of biomolecules associated therewith BIACORE AB (SE) 2001-09-11 US claimed
WO-2001060961-A1 STABLE, AQUEOUS COMPOSITIONS FOR TREATING SURFACES, ESPECIALLY FABRICS THE PROCTER & GAMBLE COMPANY (US) 2001-08-23 WO claimed
EP-1082607-A1 SURFACE REGENERATION OF BIOSENSORS Biacore AB (SE) 2001-03-14 EP claimed
US-6197823-B1 Pain reliever and method of use MEDICAL MERCHANDISING, INC. 2001-03-06 US claimed
WO-1999063333-A1 SURFACE REGENERATION OF BIOSENSORS BIACORE AB (SE) 1999-12-09 WO claimed
EP-0456806-B1 HISTIDINE BUFFERED PERITONEAL DIALYSIS SOLUTION BAXTER INT (US) 1996-12-11 EP claimed
CN-1085544-A By amino acid and chloroethanol reaction synthetic N-(2-hydroxyethyl) amino acid and N, N-two (2-hydroxyethyl) amino acid derivatives UNIV WUHAN (CN) 1994-04-20 CN claimed
US-4124391-A A P-PHENYLENEDIAMINE COLOR DEVELOPER AND A MONOSACCHARIDE AS ANTIOXIDANT FUJI PHOTO FILM CO., LTD. (JP) 1978-11-07 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020010154-A1 Compositions comprising cyclodextrin FFAR4, FRG1, FGB CYP3A4 605/4885SLC7A5 2690/4885CPB2 3645/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.