Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.70 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.55 |
| ▸ | AHR | P35869 | 2/20 | 0.53 |
| ▸ | JAK3 | P52333 | 7/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3260453 | 0.86 | JAK2 (0.72) | JAK2NUDT1JAK3JAK1PTK2 | |
| SCHEMBL15796859 | 0.86 | JAK2 (0.72) | JAK2NUDT1JAK3JAK1PTK2 | |
| SCHEMBL18367046 | 0.85 | JAK2 (0.77) | JAK2NUDT1JAK3JAK1PTK2 | |
| SCHEMBL2251442 | 0.84 | JAK2 (0.70) | JAK2NUDT1JAK3JAK1PTK2 | |
| SCHEMBL2254342 | 0.84 | JAK2 (0.72) | JAK2NUDT1JAK3JAK1PTK2 | |
| SCHEMBL2640477 | 0.83 | JAK2 (1.00) | JAK2NUDT1JAK3JAK1PTK2 | |
| SCHEMBL2257705 | 0.82 | JAK2 (0.64) | JAK2NUDT1AHRJAK3JAK1 | |
| SCHEMBL2640435 | 0.81 | AHR (0.53) | JAK2NUDT1AHRJAK3JAK1 | |
| SCHEMBL3260459 | 0.81 | JAK2 (0.65) | JAK2NUDT1JAK3JAK1PTK2 | |
| SCHEMBL1691216 | 0.81 | JAK2 (0.68) | JAK2NUDT1JAK3JAK1PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010186-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |