Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.72 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 9/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3260453 | 0.86 | JAK2 (0.72) | JAK2NUDT1JAK3JAK1PTK2 | |
| SCHEMBL15796859 | 0.86 | JAK2 (0.72) | JAK2NUDT1JAK3JAK1ALDH1A3 | |
| SCHEMBL18367046 | 0.85 | JAK2 (0.77) | JAK2NUDT1JAK3JAK1ALDH1A3 | |
| SCHEMBL2257705 | 0.85 | JAK2 (0.64) | JAK2NUDT1JAK3JAK1PTK2 | |
| SCHEMBL2251442 | 0.84 | JAK2 (0.70) | JAK2NUDT1JAK3JAK1ALDH1A3 | |
| SCHEMBL3260096 | 0.84 | JAK2 (0.70) | JAK2NUDT1JAK3JAK1PTK2 | |
| SCHEMBL12517030 | 0.84 | JAK2 (0.63) | JAK2NUDT1JAK3JAK1PTK2 | |
| SCHEMBL2640589 | 0.84 | JAK2 (1.00) | JAK2NUDT1JAK3JAK1PTK2 | |
| SCHEMBL18615164 | 0.84 | JAK2 (0.67) | JAK2NUDT1JAK3JAK1PTK2 | |
| SCHEMBL18615199 | 0.83 | JAK2 (0.64) | JAK2NUDT1JAK3JAK1PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339161-B2 | Triazolo pyridines as modulators of gamma-secretase | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-05-24 | — | — | US | disclosed |
| EP-3672971-B1 | TRIAZOLO PYRIDINES AS MODULATORS OF GAMMA-SECRETASE | BOEHRINGER INGELHEIM INT (DE) | 2021-07-14 | — | — | EP | disclosed |
| US-20210017173-A1 | TRIAZOLO PYRIDINES AS MODULATORS OF GAMMA-SECRETASE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-01-21 | — | — | US | disclosed |
| CN-111465603-A | Triazolopyridines as gamma-secretase modulators | 勃林格殷格翰国际有限公司 | 2020-07-28 | — | — | CN | disclosed |
| EP-3672971-A1 | TRIAZOLO PYRIDINES AS MODULATORS OF GAMMA-SECRETASE | Boehringer Ingelheim International GmbH (DE) | 2020-07-01 | — | — | EP | disclosed |
| EP-2536710-B1 | PIPERIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-07-13 | — | — | EP | disclosed |
| US-9145399-B2 | Substituted bicyclic triazole derivatives as gamma secretase modulators | Janssen Pharmaceuticals, Inc. (US) | 2015-09-29 | — | — | US | disclosed |
| US-9145399-B2 | Substituted bicyclic triazole derivatives as gamma secretase modulators | Janssen Pharmaceuticals, Inc. (US) | 2015-09-29 | — | — | US | disclosed |
| US-8946266-B2 | Substituted triazole and imidazole derivatives as gamma secretase modulators | Janssen Pharmaceuticals, Inc. (US) | 2015-02-03 | — | — | US | disclosed |
| US-8946266-B2 | Substituted triazole and imidazole derivatives as gamma secretase modulators | Janssen Pharmaceuticals, Inc. (US) | 2015-02-03 | — | — | US | disclosed |
| US-20120295901-A1 | NOVEL SUBSTITUTED BICYCLIC TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | CELLZOME LIMITED (GB) | 2012-11-22 | — | — | US | disclosed |
| US-20120295901-A1 | NOVEL SUBSTITUTED BICYCLIC TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | CELLZOME LIMITED (GB) | 2012-11-22 | — | — | US | disclosed |
| US-20120135981-A1 | NOVEL SUBSTITUTED TRIAZOLE AND IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | CELLZOME LIMITED (GB) | 2012-05-31 | — | — | US | disclosed |
| US-20120135981-A1 | NOVEL SUBSTITUTED TRIAZOLE AND IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | CELLZOME LIMITED (GB) | 2012-05-31 | — | — | US | disclosed |
| WO-2011101304-A2 | PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-25 | — | — | WO | disclosed |
| US-20110201605-A1 | HETEROARYL SUBSTITUTED PIPERIDINES | HOFFMANN-LA ROCHE, INC. | 2011-08-18 | — | — | US | disclosed |
| WO-2011092272-A1 | GAMMA SECRETASE MODULATERS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-04 | — | — | WO | disclosed |
| US-20110190269-A1 | GAMMA SECRETASE MODULATORS | HOFFMANN-LA ROCHE, INC. | 2011-08-04 | — | — | US | disclosed |
| WO-2011086098-A1 | NOVEL SUBSTITUTED BICYCLIC TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2011-07-21 | — | — | WO | disclosed |
| WO-2011006903-A1 | SUBSTITUTED TRIAZOLE AND IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2011-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210017173-A1 | TRIAZOLO PYRIDINES AS MODULATORS OF GAMMA-SECRETASE | BACE1, BACE2, APP | JAK2 4676/4885NUDT1 3445/4885JAK3 4393/4885 |
| US-20110190269-A1 | GAMMA SECRETASE MODULATORS | BACE1, APH1A, APH1B | JAK2 4637/4885NUDT1 1834/4885JAK3 4543/4885 |
| US-20120135981-A1 | NOVEL SUBSTITUTED TRIAZOLE AND IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | BACE1, BACE2, APH1A | JAK2 4166/4885NUDT1 2016/4885JAK3 2640/4885 |
| US-20110201605-A1 | HETEROARYL SUBSTITUTED PIPERIDINES | APP, HPGDS, PSEN1 | JAK2 3153/4885NUDT1 1439/4885JAK3 4312/4885 |
| US-20120295901-A1 | NOVEL SUBSTITUTED BICYCLIC TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | BACE1, BACE2, APH1A | JAK2 4105/4885NUDT1 2255/4885JAK3 3487/4885 |
| US-11339161-B2 | Triazolo pyridines as modulators of gamma-secretase | BACE1, BACE2, APP | JAK2 4676/4885NUDT1 3445/4885JAK3 4393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.