Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 3/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3755119 | 1.00 | TMEM97 (0.39) | TMEM97P2RY14DRD1SIGMAR1MEN1 | |
| SCHEMBL3746870 | 0.89 | GRM2 (0.41) | TMEM97P2RY14DRD1SIGMAR1MEN1 | |
| SCHEMBL3759380 | 0.86 | TMEM97 (0.51) | TMEM97P2RY14DRD1SIGMAR1 | |
| SCHEMBL3749731 | 0.86 | P2RY14 (0.43) | TMEM97P2RY14DRD1SIGMAR1 | |
| SCHEMBL2934955 | 0.78 | BCL2L1 (0.47) | P2RY14MEN1ALDH1A1LMNAMAPT | |
| SCHEMBL2930789 | 0.76 | TMEM97 (0.51) | TMEM97P2RY14DRD1SIGMAR1 | |
| SCHEMBL2927418 | 0.73 | TMEM97 (0.46) | TMEM97P2RY14DRD1SIGMAR1 | |
| SCHEMBL3752178 | 0.73 | P2RY14 (0.46) | TMEM97P2RY14DRD1SIGMAR1 | |
| SCHEMBL2929310 | 0.72 | ALDH1A1 (0.41) | TMEM97P2RY14MEN1ALDH1A1LMNA | |
| SCHEMBL3761498 | 0.70 | P2RY14 (0.61) | TMEM97P2RY14DRD1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229373-A1 | SUBSTITUTED 2-NAPHTHOIC ACIDS AS ANTAGONISTS OF GPR105 ACTIVITY | Merck Frosst Canada Ltd. (CA) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009070873-A1 | SUBSTITUTED 2-NAPHTHOIC ACIDS AS ANTAGONISTS OF GPR105 ACTIVITY | MERCK FROSST CANADA LTD. (CA) | 2009-06-11 | — | — | WO | disclosed |