Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | CDK1 | P06493 | 3/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 10/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.34 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3260742 | 0.89 | CCNE1 (0.40) | CCNE1CDK2CDK1CCNB1CYP1A2 | |
| SCHEMBL3288028 | 0.82 | POLB (0.36) | CCNE1CDK2CDK1CCNB1HSP90AB1 | |
| SCHEMBL4274883 | 0.82 | CDK1 (0.35) | CCNE1CDK2CDK1CCNB1CYP1A2 | |
| SCHEMBL3000249 | 0.82 | PDE4A (0.38) | CCNE1CDK2CDK1CCNB1CYP1A2 | |
| SCHEMBL3000253 | 0.82 | PDE4A (0.38) | CCNE1CDK2CDK1CCNB1CYP1A2 | |
| SCHEMBL2912568 | 0.78 | PDE4A (0.35) | CCNE1CDK2CDK1CCNB1HSP90AB1 | |
| SCHEMBL22224843 | 0.76 | CCNE1 (0.49) | CCNE1CDK2CDK1CCNB1CYP1A2 | |
| SCHEMBL27595143 | 0.76 | CCNE1 (0.43) | CCNE1CDK2CDK1CCNB1CYP1A2 | |
| SCHEMBL27580729 | 0.76 | CDK1 (0.46) | CCNE1CDK2CDK1CCNB1CYP1A2 | |
| SCHEMBL4273048 | 0.74 | FAP (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004440-A1 | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | CHO DONG-GYU | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004440-A1 | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | PNP, ITPA, MTAP | CCNE1 1216/4885CDK2 671/4885CDK1 452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.