Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | LPL | P06858 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3225882 | 0.76 | PRMT5 (0.40) | EGFRLPLLIPGIDO1TDO2 | |
| SCHEMBL3263058 | 0.73 | PRMT5 (0.40) | EGFRLPLLIPGIDO1TDO2 | |
| SCHEMBL20600698 | 0.72 | LPL (0.37) | EGFRLPLLIPGROCK1 | |
| SCHEMBL3226647 | 0.70 | PIM1 (0.41) | — | |
| SCHEMBL25025760 | 0.70 | GSK3A (0.35) | EGFRLPLLIPGGSK3AGSK3B | |
| SCHEMBL30233508 | 0.70 | GSK3A (0.35) | EGFRLPLLIPGGSK3AGSK3B | |
| SCHEMBL29016499 | 0.68 | LPL (0.47) | EGFRLPLLIPGROCK1 | |
| SCHEMBL22690886 | 0.68 | LPL (0.41) | LPLLIPGIDO1TDO2PRMT5 | |
| SCHEMBL1564647 | 0.68 | LPL (0.41) | LPLLIPGROCK1 | |
| SCHEMBL6691092 | 0.68 | LPL (0.50) | LPLLIPGROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020366-A1 | AZABICYCLIC SUBSTITUTED 5-AMINOPYRAZOLES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-02-25 | — | — | WO | disclosed |
| WO-2010020366-A1 | AZABICYCLIC SUBSTITUTED 5-AMINOPYRAZOLES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-02-25 | — | — | WO | disclosed |