Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | VEGFA | P15692 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PDE1A | P54750 | 1/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359838 | 0.85 | PDE4B (0.55) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7357311 | 0.80 | PDE4B (0.57) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5823060 | 0.77 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6919617 | 0.76 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7364691 | 0.76 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2371130 | 0.73 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7548438 | 0.73 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6817584 | 0.73 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3375192 | 0.73 | MAPT (0.69) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL8523190 | 0.72 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010029299-A1 | PYRIMIDINONE DERIVATIES FOR USE AS MEDICAMENTS | BIOLIPOX AB (SE) | 2010-03-18 | — | — | WO | disclosed |