Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | NNMT | P40261 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | MPO | P05164 | 1/20 | 0.30 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3241826 | 0.93 | HDAC1 (0.36) | HDAC3HDAC1POLBTDP1PLAU | |
| SCHEMBL3230242 | 0.85 | HDAC1 (0.43) | HDAC3HDAC1POLBTDP1PLAU | |
| SCHEMBL3241080 | 0.75 | MPO (0.40) | HDAC3HDAC1MPO | |
| SCHEMBL3232050 | 0.74 | HDAC3 (0.40) | HDAC3HDAC1MPO | |
| SCHEMBL3236826 | 0.73 | KDM4E (0.38) | HDAC3HDAC1TDP1 | |
| SCHEMBL3233744 | 0.73 | KMT2A (0.47) | HDAC3HDAC1TDP1 | |
| SCHEMBL3232041 | 0.71 | HDAC1 (0.34) | HDAC3HDAC1CDK9MPO | |
| SCHEMBL3237150 | 0.71 | HDAC1 (0.41) | HDAC3HDAC1MPO | |
| SCHEMBL3238235 | 0.71 | HDAC3 (0.33) | HDAC3HDAC1ACHE | |
| SCHEMBL3230030 | 0.70 | MAPT (0.43) | HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |