Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MMP2 | P08253 | 4/20 | 0.34 |
| ▸ | ANPEP | P15144 | 4/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2281174 | 1.00 | MAPT (0.39) | MAPTPIM1PIM3PIM2KMT2A | |
| SCHEMBL2281170 | 1.00 | MAPT (0.39) | MAPTPIM1PIM3PIM2KMT2A | |
| SCHEMBL3262271 | 1.00 | MAPT (0.39) | MAPTPIM1PIM3PIM2KMT2A | |
| SCHEMBL4433871 | 0.89 | MEN1 (0.41) | MAPTKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL4119028 | 0.88 | KDM4D (0.36) | MAPTPIM1PIM3PIM2KMT2A | |
| SCHEMBL3263210 | 0.88 | MAPT (0.34) | MAPTKMT2AMEN1HTTGAA | |
| SCHEMBL4435515 | 0.88 | MAPT (0.34) | MAPTKMT2AMEN1HTTGAA | |
| SCHEMBL14972648 | 0.88 | MAPT (0.34) | MAPTKMT2AMEN1HTTGAA | |
| SCHEMBL14972645 | 0.88 | MAPT (0.34) | MAPTKMT2AMEN1HTTGAA | |
| SCHEMBL4435520 | 0.88 | MAPT (0.34) | MAPTKMT2AMEN1HTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010026122-A1 | HETEROCYCLIC PIM-KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-03-11 | — | — | WO | disclosed |