Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.61 |
| ▸ | JAK3 | P52333 | 5/20 | 0.48 |
| ▸ | JAK1 | P23458 | 2/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 4/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | RHOA | P61586 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3303680 | 0.88 | JAK2 (0.49) | JAK2JAK3JAK1TYK2PTK2 | |
| SCHEMBL2144680 | 0.86 | JAK2 (0.51) | JAK2JAK3JAK1PTK2RXFP1 | |
| SCHEMBL3262435 | 0.86 | JAK2 (0.55) | JAK2JAK3JAK1TYK2PTK2 | |
| SCHEMBL7964132 | 0.85 | JAK2 (0.49) | JAK2JAK3JAK1TYK2PTK2 | |
| SCHEMBL3266110 | 0.84 | JAK2 (0.55) | JAK2JAK3JAK1TYK2PTK2 | |
| SCHEMBL3200947 | 0.84 | JAK2 (0.83) | JAK2JAK3JAK1PTK2 | |
| SCHEMBL3261713 | 0.83 | JAK1 (0.64) | JAK2JAK3JAK1PTK2SMN1; SMN2 | |
| SCHEMBL3303044 | 0.83 | JAK2 (0.77) | JAK2JAK3JAK1PTK2 | |
| SCHEMBL7974556 | 0.82 | MEN1 (0.55) | JAK2JAK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3263724 | 0.81 | JAK2 (0.45) | JAK2JAK3JAK1PTK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010189-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010189-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |