Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3262435 | 0.89 | JAK2 (0.55) | MEN1KMT2AJAK2RXFP1KDM4E | |
| SCHEMBL3262347 | 0.82 | JAK2 (0.61) | RAB9ATHRBJAK2RXFP1NPC1 | |
| SCHEMBL2144680 | 0.81 | JAK2 (0.51) | MEN1KMT2AJAK2RXFP1JAK1 | |
| SCHEMBL13072986 | 0.81 | JAK2 (0.76) | MEN1KMT2ARAB9ATHRBJAK2 | |
| SCHEMBL3303680 | 0.81 | JAK2 (0.49) | JAK2JAK1 | |
| SCHEMBL7964132 | 0.81 | JAK2 (0.49) | MEN1KMT2AJAK2LMNAALDH1A1 | |
| SCHEMBL3657387 | 0.80 | JAK2 (0.61) | MEN1KMT2ARAB9ATHRBJAK2 | |
| SCHEMBL3261713 | 0.79 | JAK1 (0.64) | KMT2AJAK2POLBLMNASMN1; SMN2 | |
| SCHEMBL23754204 | 0.77 | ADORA3 (0.49) | KMT2AALDH1A1HTTL3MBTL1CYP1A2 | |
| SCHEMBL12253193 | 0.76 | MEN1 (0.83) | MEN1KMT2ARAB9ATHRBPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |