Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 18/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.66 |
| ▸ | CDC42BPA | Q5VT25 | 4/20 | 0.66 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.43 |
| ▸ | PRKACB | P22694 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13457432 | 0.90 | ROCK2 (0.70) | ROCK2ROCK1CDC42BPAMAPK10CYP3A4 | |
| SCHEMBL3265194 | 0.89 | ROCK2 (0.78) | ROCK2ROCK1CDC42BPAMAPK10CYP3A4 | |
| SCHEMBL3261889 | 0.88 | ROCK2 (0.71) | ROCK2ROCK1CDC42BPAMAPK10CYP3A4 | |
| SCHEMBL13457522 | 0.86 | ROCK2 (0.86) | ROCK2ROCK1CDC42BPAMAPK10CYP3A4 | |
| SCHEMBL13457384 | 0.86 | ROCK2 (0.68) | ROCK2ROCK1CDC42BPAMAPK10CYP3A4 | |
| SCHEMBL3260236 | 0.84 | ROCK2 (0.66) | ROCK2ROCK1CDC42BPAMAPK10CYP3A4 | |
| SCHEMBL13457050 | 0.82 | ROCK2 (0.84) | ROCK2ROCK1CDC42BPAMAPK10CYP3A4 | |
| SCHEMBL3251667 | 0.81 | ROCK2 (0.73) | ROCK2ROCK1CDC42BPACYP3A4CYP2D6 | |
| SCHEMBL13457123 | 0.81 | ROCK2 (1.00) | ROCK2ROCK1CDC42BPAMAPK10CYP3A4 | |
| SCHEMBL13457098 | 0.80 | ROCK2 (1.00) | ROCK2ROCK1CDC42BPAMAPK10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010024903-A1 | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-03-04 | — | — | WO | disclosed |