Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2995959 | 0.89 | ALDH1A1 (0.59) | ALDH1A1POLBGAAHPGDHTT | |
| SCHEMBL3002781 | 0.88 | ALDH1A1 (0.60) | ALDH1A1POLBGAAHPGDHTT | |
| SCHEMBL2995850 | 0.87 | ALDH1A1 (0.47) | ALDH1A1POLBGAAHPGDHTT | |
| SCHEMBL3003474 | 0.86 | ALDH1A1 (0.61) | ALDH1A1POLBHPGDHTTLMNA | |
| SCHEMBL2996987 | 0.84 | ALDH1A1 (0.49) | ALDH1A1POLBHPGDHTTLMNA | |
| SCHEMBL2999562 | 0.77 | ALDH1A1 (0.63) | ALDH1A1POLBHPGDHTTLMNA | |
| SCHEMBL2990618 | 0.76 | ALDH1A1 (0.53) | ALDH1A1POLBGAAHPGDHTT | |
| SCHEMBL3115427 | 0.76 | ALDH1A1 (0.57) | ALDH1A1POLBGAAHTTLMNA | |
| SCHEMBL3006666 | 0.76 | ALDH1A1 (0.51) | ALDH1A1POLBGAAHPGDHTT | |
| SCHEMBL3003501 | 0.76 | ALDH1A1 (0.60) | ALDH1A1POLBGAAHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002483-A1 | OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |