Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1045955 | 0.86 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL1046002 | 0.84 | LMNA (0.46) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL1042896 | 0.84 | LMNA (0.48) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL1044567 | 0.82 | MAPT (0.45) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL1046876 | 0.81 | TOP1 (0.45) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL1044543 | 0.81 | LMNA (0.46) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL1044962 | 0.81 | GAA (0.51) | ALDH1A1CNR2LMNACHRM1HTT | |
| SCHEMBL1044465 | 0.81 | LMNA (0.46) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL1046189 | 0.81 | TP53 (0.47) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL1043877 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1HPGDHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1564210-B9 | 4-OXOQUINOLINE COMPOUNDS AND UTILIZATION THEREOF AS HIV INTEGRASE INHIBITORS | JAPAN TOBACCO INC (JP) | 2010-03-31 | — | — | EP | disclosed |
| EP-1564210-B1 | 4-OXOQUINOLINE COMPOUNDS AND UTILIZATION THEREOF AS HIV INTEGRASE INHIBITORS | JAPAN TOBACCO INC (JP) | 2009-09-16 | — | — | EP | disclosed |