Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 8/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3263610 | 1.00 | BTK (0.46) | BTKLCKJAK3EGFRKMT2A | |
| SCHEMBL3263930 | 0.90 | EGFR (0.42) | BTKLCKJAK3EGFRMAP4K1 | |
| SCHEMBL3263927 | 0.90 | EGFR (0.42) | BTKLCKJAK3EGFRMAP4K1 | |
| SCHEMBL13303594 | 0.78 | BTK (0.46) | BTKLCKJAK3EGFRKMT2A | |
| SCHEMBL3264947 | 0.78 | BTK (0.50) | BTKLCKJAK3EGFRKMT2A | |
| SCHEMBL3264950 | 0.78 | BTK (0.50) | BTKLCKJAK3EGFRKMT2A | |
| SCHEMBL30024031 | 0.70 | EGFR (0.57) | BTKJAK3EGFRMAP4K1 | |
| SCHEMBL28870255 | 0.70 | EGFR (0.57) | BTKJAK3EGFRMAP4K1 | |
| SCHEMBL3240119 | 0.69 | LCK (0.48) | BTKLCKJAK3EGFRKMT2A | |
| SCHEMBL3242367 | 0.68 | LCK (0.48) | BTKLCKJAK3EGFRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068806-A1 | AMIDE DERIVATIVES AS BTK INHIBITORS IN THE TREATMENT OF ALLERGIC, AUTOIMMUNE AND INFLAMMATORY DISORDERS AS WELL AS CANCER | CGI PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | claimed |