Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 8/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 4/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.42 |
| ▸ | ROS1 | P08922 | 2/20 | 0.42 |
| ▸ | CCNK | O75909 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3232842 | 0.92 | ROS1 (0.43) | LCKJAK3EGFRHRH4BTK | |
| SCHEMBL3242367 | 0.90 | LCK (0.48) | LCKJAK3EGFRHRH4BTK | |
| SCHEMBL3263743 | 0.85 | LCK (0.40) | LCKJAK3EGFRHRH4BTK | |
| SCHEMBL3263746 | 0.85 | LCK (0.40) | LCKJAK3EGFRHRH4BTK | |
| SCHEMBL3236597 | 0.82 | BTK (0.43) | LCKJAK3EGFRBTKCCND3 | |
| SCHEMBL3263927 | 0.73 | EGFR (0.42) | LCKJAK3EGFRBTK | |
| SCHEMBL3263930 | 0.73 | EGFR (0.42) | LCKJAK3EGFRBTK | |
| SCHEMBL28322975 | 0.69 | JAK3 (0.72) | LCKJAK3EGFRBTK | |
| SCHEMBL3263610 | 0.69 | BTK (0.46) | LCKJAK3EGFRBTKKMT2A | |
| SCHEMBL3263603 | 0.69 | BTK (0.46) | LCKJAK3EGFRBTKKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068806-A1 | AMIDE DERIVATIVES AS BTK INHIBITORS IN THE TREATMENT OF ALLERGIC, AUTOIMMUNE AND INFLAMMATORY DISORDERS AS WELL AS CANCER | CGI PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | claimed |