Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12335228 | 1.00 | POLB (0.53) | POLBTDP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13102956 | 0.96 | POLB (0.49) | POLBTDP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27630749 | 0.94 | POLB (0.46) | POLBTDP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9864629 | 0.92 | POLB (0.49) | POLBTDP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9731595 | 0.90 | POLB (0.48) | POLBTDP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9731600 | 0.90 | POLB (0.48) | POLBTDP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9732288 | 0.88 | DPP7 (0.50) | POLBTDP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9732284 | 0.88 | DPP7 (0.50) | POLBTDP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17001739 | 0.86 | TDP1 (0.46) | POLBTDP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12506229 | 0.85 | POLB (0.44) | POLBTDP1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078001-B1 | DIAZEPANE-ACETAMIDE DERIVATIVES AS SELECTIVE 11 -HSD1 INHIBITORS | MERCK PATENT GMBH (DE) | 2010-05-12 | — | — | EP | claimed |