Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9731600 | 1.00 | POLB (0.48) | POLBTDP1DPP7NPC1RAB9A | |
| SCHEMBL9864629 | 0.98 | POLB (0.49) | POLBTDP1DPP7NPC1RAB9A | |
| SCHEMBL9732284 | 0.94 | DPP7 (0.50) | POLBTDP1DPP7NPC1RAB9A | |
| SCHEMBL9732288 | 0.94 | DPP7 (0.50) | POLBTDP1DPP7NPC1RAB9A | |
| SCHEMBL12335228 | 0.90 | POLB (0.53) | POLBTDP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3264155 | 0.90 | POLB (0.53) | POLBTDP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13102956 | 0.86 | POLB (0.49) | POLBTDP1DPP7NPC1RAB9A | |
| SCHEMBL27630749 | 0.83 | POLB (0.46) | POLBTDP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12506229 | 0.83 | POLB (0.44) | POLBTDP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10519635 | 0.82 | POLB (0.47) | POLBTDP1DPP7NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5101039-A | Carboxyindoles, hypotensive agents, inhibitors of angiotensin converting enzyme | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-03-31 | — | — | US | disclosed |
| US-5008400-A | Chemical intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-04-16 | — | — | US | disclosed |
| US-4933361-A | HYPOTENSIVE AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-06-12 | — | — | US | disclosed |
| EP-0170775-B1 | DERIVATIVES OF BICYCLIC AMINO ACIDS, PROCESSES FOR THEIR PREPARATION, AGENTS CONTAINING THEM AND THEIR USE AS WELL AS BICYCLIC AMINO ACIDS AS INTERMEDIATES AND PROCESS FOR THEIR PREPARATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-11-08 | — | — | EP | disclosed |
| EP-0084164-A2 | Derivatives of bicyclic amino acids, process for their preparation, agents containing them and their use, as well as bicyclic amino acids as intermediates, and process for preparing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-07-27 | — | — | EP | disclosed |