Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 18/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 18/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250185 | 0.88 | MTNR1A (0.46) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL3251496 | 0.88 | MTNR1A (0.49) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL3256717 | 0.88 | MTNR1A (0.60) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL3253497 | 0.84 | MTNR1A (0.48) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL6437518 | 0.81 | MTNR1A (0.36) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL3248612 | 0.78 | MTNR1A (0.48) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| Citric Acid SCHEMBL3248609 | 0.77 | MTNR1A (0.55) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| Dimethylamine SCHEMBL3256880 | 0.77 | MTNR1A (0.48) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL3245162 | 0.76 | MTNR1A (0.46) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL3251452 | 0.76 | MTNR1A (0.50) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537113-B9 | ARYLALKYL INDOLES HAVING SEROTONIN RECEPTOR AFFINITY USEFUL AS THERAPEUTIC AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SUVEN LIFE SCIENCES LTD (IN) | 2010-05-26 | — | — | EP | disclosed |
| US-7297711-B2 | Arylalkyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them | SUVEN LIFE SCIENCES LIMITED (IN) | 2007-11-20 | — | — | US | disclosed |