Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 16/20 | 0.90 |
| ▸ | BCR | P11274 | 13/20 | 0.90 |
| ▸ | KIT | P10721 | 12/20 | 0.90 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.90 |
| ▸ | PDGFRA | P16234 | 10/20 | 0.76 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.76 |
| ▸ | ABL2 | P42684 | 3/20 | 0.76 |
| ▸ | SRC | P12931 | 2/20 | 0.76 |
| ▸ | SYK | P43405 | 2/20 | 0.76 |
| ▸ | PLK4 | O00444 | 1/20 | 0.76 |
| ▸ | DDX3X | O00571 | 1/20 | 0.76 |
| ▸ | GAK | O14976 | 1/20 | 0.76 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.76 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.76 |
| ▸ | CA12 | O43570 | 1/20 | 0.76 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.76 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.76 |
| ▸ | EGFR | P00533 | 1/20 | 0.76 |
| ▸ | CA1 | P00915 | 1/20 | 0.76 |
| ▸ | CA2 | P00918 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3064834 | 0.96 | ABL1 (0.90) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL846536 | 0.95 | ABL1 (1.00) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL29410182 | 0.95 | ABL1 (1.00) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL4405514 | 0.92 | ABL1 (1.00) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL19586397 | 0.90 | ABL1 (0.89) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL3068704 | 0.90 | ABL1 (0.80) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL31553098 | 0.89 | ABL1 (0.94) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL4394539 | 0.88 | ABL1 (0.88) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL3058299 | 0.88 | ABL1 (0.86) | ABL1BCRKITLRRK2PDGFRA | |
| Imatinib SCHEMBL22418872 | 0.88 | ABL1 (1.00) | ABL1BCRKITLRRK2PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010019557-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2010-02-18 | — | — | WO | disclosed |