Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 16/20 | 0.80 |
| ▸ | BCR | P11274 | 12/20 | 0.80 |
| ▸ | KIT | P10721 | 12/20 | 0.80 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.80 |
| ▸ | PDGFRA | P16234 | 10/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.68 |
| ▸ | ABL2 | P42684 | 3/20 | 0.68 |
| ▸ | EGFR | P00533 | 2/20 | 0.68 |
| ▸ | PLK4 | O00444 | 1/20 | 0.68 |
| ▸ | DDX3X | O00571 | 1/20 | 0.68 |
| ▸ | GAK | O14976 | 1/20 | 0.68 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.68 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.68 |
| ▸ | CA12 | O43570 | 1/20 | 0.68 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | CA1 | P00915 | 1/20 | 0.68 |
| ▸ | CA2 | P00918 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | ALB | P02768 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3064834 | 0.94 | ABL1 (0.90) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL13138679 | 0.91 | ABL1 (0.70) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL3264382 | 0.90 | ABL1 (0.90) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL29410182 | 0.89 | ABL1 (1.00) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL846536 | 0.89 | ABL1 (1.00) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL3072795 | 0.87 | ABL1 (0.65) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL4405514 | 0.86 | ABL1 (1.00) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL13138678 | 0.86 | ABL1 (0.76) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL3071844 | 0.85 | PDGFRA (0.80) | ABL1BCRKITLRRK2PDGFRA | |
| SCHEMBL19586397 | 0.84 | ABL1 (0.89) | ABL1BCRKITLRRK2PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130121963-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2013-05-16 | — | — | US | disclosed |
| US-20100221221-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2010-09-02 | — | — | US | disclosed |
| US-20100221221-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130121963-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | NME2, NME1, ABL1 | ABL1 3/4885BCR 841/4885KIT 1603/4885 |
| US-20100221221-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | NME2, NME1, ABL1 | ABL1 3/4885BCR 841/4885KIT 1603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.