Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18160331 | 0.83 | MAPT (0.47) | MAPTMEN1KMT2AL3MBTL1PSMD14 | |
| SCHEMBL18157762 | 0.80 | ALK (0.50) | MAPTMEN1KMT2AL3MBTL1PSMD14 | |
| SCHEMBL28266883 | 0.75 | MAPT (0.50) | MAPTMEN1KMT2ACYP2D6CYP3A4 | |
| SCHEMBL31157158 | 0.75 | MAPT (0.50) | MAPTMEN1KMT2ACYP2D6CYP3A4 | |
| SCHEMBL20225455 | 0.75 | CYP11B1 (0.51) | MAPTMEN1KMT2AL3MBTL1PSMD14 | |
| SCHEMBL11953116 | 0.71 | MAPT (0.48) | MAPTMEN1KMT2ACYP2D6CYP3A4 | |
| SCHEMBL30159432 | 0.71 | HSP90AA1 (0.42) | MAPTMEN1KMT2ACYP2D6CYP3A4 | |
| SCHEMBL18132168 | 0.71 | AHR (0.47) | MAPTMEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL18160168 | 0.70 | ALDH1A1 (0.51) | MAPTMEN1KMT2AL3MBTL1CYP2D6 | |
| SCHEMBL13907337 | 0.69 | MAPT (0.54) | MAPTMEN1KMT2ACYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008427-A1 | TRYPTOPHAN CATABOLISM IN CANCER TREATMENT AND DIAGNOSIS | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD. (US) | 2010-01-21 | — | — | WO | disclosed |