Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 16/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.47 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16458523 | 0.90 | ADORA3 (0.63) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL15111844 | 0.90 | PDE5A (0.55) | PDE5AADORA3KCNH2 | |
| SCHEMBL15111741 | 0.82 | PDE5A (0.56) | PDE5AADORA3KCNH2 | |
| SCHEMBL15111642 | 0.81 | ADORA3 (0.60) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL15111641 | 0.81 | ADORA3 (0.62) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL16594848 | 0.81 | ADORA3 (0.62) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL15519039 | 0.81 | PDE5A (0.56) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL15111846 | 0.80 | PDE5A (0.61) | PDE5AADORA3KCNH2 | |
| SCHEMBL15111795 | 0.80 | PDE5A (0.54) | PDE5AADORA3KCNH2 | |
| SCHEMBL16458187 | 0.80 | ADORA3 (0.55) | PDE5AADORA3KCNH2GUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2708539-A1 | Annulated pyrimidines and triazines and their use | Bayer Intellectual Property GmbH (DE) | 2014-03-19 | — | — | EP | disclosed |
| EP-2682394-A1 | 1H-pyrazolo[3,4-b]pyridin-triazine derivatives and their use for the treatment or the prevention of cardiovascular diseases | Bayer Intellectual Property GmbH (DE) | 2014-01-08 | — | — | EP | disclosed |
| EP-2590979-A1 | RING-FUSED PYRIMIDINES AND TRIAZINES AND USE THEREOF FOR THE TREATMENT AND/OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES | Bayer Intellectual Property GmbH (DE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004258-A9 | RING-FUSED PYRIMIDINES AND TRIAZINES AND USE THEREOF FOR THE TREATMENT AND/OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-07 | — | — | WO | disclosed |
| WO-2012004258-A1 | RING-FUSED PYRIMIDINES AND TRIAZINES AND USE THEREOF FOR THE TREATMENT AND/OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-12 | — | — | WO | disclosed |