Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 15/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264633 | 1.00 | KCNH2 (0.47) | KCNH2TACR1RENCYP3A4PDE4B | |
| SCHEMBL556513 | 1.00 | KCNH2 (0.47) | KCNH2TACR1RENCYP3A4PDE4B | |
| SCHEMBL1750732 | 0.91 | PDE4B (0.51) | KCNH2TACR1RENCYP3A4PDE4B | |
| SCHEMBL1751490 | 0.91 | PDE4B (0.51) | KCNH2TACR1RENCYP3A4PDE4B | |
| SCHEMBL2783355 | 0.91 | REN (0.43) | KCNH2TACR1RENCYP3A4PDE4B | |
| SCHEMBL2783354 | 0.91 | REN (0.43) | KCNH2TACR1RENCYP3A4PDE4B | |
| SCHEMBL4100936 | 0.89 | KCNH2 (0.47) | KCNH2RENCYP3A4 | |
| SCHEMBL3050463 | 0.89 | KCNH2 (0.47) | KCNH2RENCYP3A4 | |
| SCHEMBL4100940 | 0.89 | KCNH2 (0.47) | KCNH2RENCYP3A4 | |
| SCHEMBL3053444 | 0.88 | REN (0.44) | KCNH2TACR1RENPDE4BGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097377-B1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2010-07-07 | — | — | EP | disclosed |