Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 19/20 | 1.00 |
| ▸ | HTR2B | P41595 | 18/20 | 1.00 |
| ▸ | HTR2A | P28223 | 5/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30396809 | 1.00 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| Hydrochloric Acid SCHEMBL7233743 | 0.98 | HTR2C (0.97) | HTR2CHTR2BHTR2A | |
| SCHEMBL24187385 | 0.91 | HTR2C (0.83) | HTR2CHTR2BHTR2A | |
| SCHEMBL691824 | 0.91 | HTR2C (0.83) | HTR2CHTR2BHTR2A | |
| SCHEMBL15202984 | 0.87 | HTR2C (0.77) | HTR2CHTR2BHTR2A | |
| SCHEMBL21788625 | 0.84 | HTR2C (0.73) | HTR2CHTR2BHTR2A | |
| SCHEMBL5322262 | 0.83 | HTR2C (0.73) | HTR2CHTR2BHTR2A | |
| SCHEMBL1366067 | 0.83 | HTR2C (0.73) | HTR2CHTR2BHTR2A | |
| SCHEMBL692120 | 0.82 | HTR2C (0.69) | HTR2CHTR2BHTR2A | |
| SCHEMBL19878681 | 0.79 | HTR2C (1.00) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994020497-A1 | PYRROLO-PYRIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-15 | — | — | WO | claimed |
| CN-115720578-A | Tricyclic derivative, preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2023-02-28 | — | — | CN | disclosed |
| WO-2022007866-A1 | FUSED TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | 深圳信立泰药业股份有限公司 | 2022-01-13 | — | — | WO | disclosed |
| EP-1551849-B1 | TRICYCLIC TETRAHYDROQUINOLINE ANTIBACTERIAL AGENTS | PHARMACIA & UPJOHN CO LLC (US) | 2010-07-14 | — | — | EP | disclosed |
| WO-2005118591-A1 | CONDENSED PIPERIDINE COMPOUNDS ACTING AS ADRENERGIC RECEPTOR ANTAGONISTS USEFUL IN THE TREATMENT OF PROSTATIC HYPERPLASIA AND LOWER URINARY SYMPTOMS | RANBAXY LABORATORIES LIMITED (IN) | 2005-12-15 | — | — | WO | disclosed |
| EP-1406631-A4 | DOPAMINE RECEPTOR LIGANDS AND THERAPEUTIC METHODS BASED THEREON | UNIV MICHIGAN (US) | 2005-03-23 | — | — | EP | disclosed |
| EP-1406631-A2 | DOPAMINE RECEPTOR LIGANDS AND THERAPEUTIC METHODS BASED THEREON | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2004-04-14 | — | — | EP | disclosed |
| US-6573377-B1 | Antitumor agent capable of showing its efficacy even against 5- FU drug resistant tumors | DAIICHI PHARMACEUTICALS CO., LTD. (JP) | 2003-06-03 | — | — | US | disclosed |
| WO-2002100350-A2 | DOPAMINE RECEPTOR LIGANDS AND THERAPEUTIC METHODS BASED THEREON | THE REGENTS OF UNIVERSITY OF MICHIGAN (US) | 2002-12-19 | — | — | WO | disclosed |
| US-5889010-A | PSYCHOLOGICAL DISORDERS; UROGENITAL DISORDERS; COGNITION ACTIVATORS; NERVOUS SYSTEM DISORDERS; VISION DEFECTS; CONGESTIVE HEART FAILURE; DRUG ABRUSE; PARKINSON'S DISEASE;ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | PFIZER INC. (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0775118-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1997-05-28 | — | — | EP | disclosed |
| US-5622950-A | Pyrrolo-pyridine derivatives | MERCK, SHARP & DOHME LTD. (GB) | 1997-04-22 | — | — | US | disclosed |
| US-5576319-A | Pyrrolo-pyridine derivatives | MERCK, SHARP & DOHME LTD. (GB) | 1996-11-19 | — | — | US | disclosed |
| WO-1996004250-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1996-02-15 | — | — | WO | disclosed |
| US-5432177-A | Pyrrolo-pyridine derivatives | MERCK SHARPE & DOHME LTD. (GB) | 1995-07-11 | — | — | US | disclosed |
| EP-0623618-A2 | Pyrrolo-pyridine derivatives | MERCK SHARP & DOHME LTD. (GB) | 1994-11-09 | — | — | EP | disclosed |
| WO-1994020497-A1 | PYRROLO-PYRIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |
| US-4681938-A | Novel polycyclic hydrazones of rifamycins, their manufacture, and their pharmaceutical compositions for treating tuberculosis | CIBA-GEIGY CORPORATION (US) | 1987-07-21 | — | — | US | disclosed |
| US-4551450-A | ANTITUBERCULOTIC AGENTS | CIBA-GEIGY CORPORATION (US) | 1985-11-05 | — | — | US | disclosed |
| EP-0135837-A2 | Polycyclic hydrazones, process for their preparation, pharmacetical compositions thereof and their use | CIBA-GEIGY AG (CH) | 1985-04-03 | — | — | EP | disclosed |