Sugi Predict

Sugi Predict / Compounds / SCHEMBL326593

SCHEMBL326593

SCHEMBL326593

Brc1cccc2c1CCN2

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ PARP10 Q53GL7 3/20 0.56
▸ PARP11 Q9NR21 3/20 0.56
▸ NOTUM Q6P988 1/20 0.44
▸ GID4 Q8IVV7 1/20 0.43
▸ PIM1 P11309 1/20 0.41
▸ CSNK1A1 P48729 1/20 0.41
▸ CDK5 Q00535 1/20 0.41
▸ ROCK1 Q13464 1/20 0.41
▸ DYRK1A Q13627 1/20 0.41
▸ LRRK2 Q5S007 1/20 0.41
▸ CLK4 Q9HAZ1 1/20 0.41
▸ DYRK1B Q9Y463 1/20 0.41
▸ NISCH Q9Y2I1 1/20 0.39
▸ PNMT P11086 1/20 0.36
▸ PARP1 P09874 3/20 0.35
▸ BCHE P06276 1/20 0.34
▸ ACHE P22303 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30661435 1.00 PARP10 (0.56) PARP10PARP11NOTUMGID4PIM1
Hydrochloric Acid SCHEMBL2422499 0.98 PARP10 (0.55) PARP10PARP11NOTUMGID4PIM1
SCHEMBL29476168 0.88 PARP10 (0.44) PARP10PARP11NOTUMGID4PIM1
SCHEMBL8650202 0.88 PARP10 (0.44) PARP10PARP11NOTUMGID4PIM1
Hydrochloric Acid SCHEMBL30147890 0.86 PARP10 (0.43) PARP10PARP11GID4PIM1CSNK1A1
SCHEMBL15523824 0.86 PARP10 (0.43) PARP10PARP11NOTUMGID4PIM1
Hydrochloric Acid SCHEMBL21598455 0.86 PARP10 (0.43) PARP10PARP11GID4PIM1CSNK1A1
SCHEMBL20539302 0.77 NOTUM (0.47) PARP10PARP11NOTUMPARP1BCHE
SCHEMBL30916119 0.77 NOTUM (0.47) PARP10PARP11NOTUMPARP1BCHE
SCHEMBL13739101 0.75 PARP10 (0.38) PARP10PARP11GID4PIM1CSNK1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 321 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117229275-B Novel 2-acetamido thiazole compound and preparation method and application thereof 北京中医药大学 2024-06-18 — — CN claimed
US-20260144788-A1 COMPOUND FOR SHP2 PROTEIN DEGRADATION AND MEDICAL USES THEREOF UBIX THERAPEUTICS, INC. (KR) 2026-05-28 — — US disclosed
CN-122070277-A Androgen receptor PROTAC 葛兰素史密斯克莱知识产权发展有限公司 2026-05-19 — — CN disclosed
US-20260125400-A1 TYK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-05-07 — — US disclosed
EP-4735438-A2 HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS Merck Patent GmbH (DE) 2026-05-06 — — EP disclosed
EP-4735452-A2 HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS PROTEIN Merck Patent GmbH (DE) 2026-05-06 — — EP disclosed
US-12590062-B2 PD-1/PD-L1 inhibitors GILEAD SCIENCES, INC. (US) 2026-03-31 — — US disclosed
US-12577231-B2 Androgen receptor PROTACS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2026-03-17 — — US disclosed
EP-4688149-A1 IRAK4 PROTACS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
US-20260001865-A1 ANDROGEN RECEPTOR PROTACS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2026-01-01 — — US disclosed
US-20080119422-A1 Indole Derivatives MITSUBISHI TANABE PHARMA CORPORATION (JP) 2008-05-22 — — US disclosed
US-20070287707-A1 Phosphodiesterase 10 inhibitors MEMORY PHARMACEUTICALS CORPORATION 2007-12-13 — — US disclosed
EP-1863798-A1 INDOLE DERIVATIVES Mitsubishi Tanabe Pharma Corporation (JP) 2007-12-12 — — EP disclosed
US-20070265258-A1 Quinazoline derivatives as phosphodiesterase 10 inhibitors AMGEN INC. 2007-11-15 — — US disclosed
WO-2007103370-A2 QUINAZOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS AMGEN INC. (US) 2007-09-13 — — WO disclosed
WO-2007100880-A1 CINNOLINE AND QUINAZOLINE DERIVATES AS PHOSPHODIESTERASE 10 INHIBITORS AMGEN INC. (US) 2007-09-07 — — WO disclosed
US-20060178381-A1 Heterocyclic-substituted phenyl methanones HOFFMANN-LA ROCHE INC. 2006-08-10 — — US disclosed
WO-2006080577-A1 INDOLE DERIVATIVES TANABE SEIYAKU CO., LTD. (JP) 2006-08-03 — — WO disclosed
US-5631280-A Inhibitors of farnesyl-protein transferase MERCK & CO., INC. (US) 1997-05-20 — — US disclosed
WO-1996030014-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 1996-10-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260125400-A1 TYK2 DEGRADERS AND USES THEREOF TYK2, CSNK2A1, CSNK2A2 PARP10 749/4885PARP11 399/4885NOTUM 3387/4885
US-20260144788-A1 COMPOUND FOR SHP2 PROTEIN DEGRADATION AND MEDICAL USES THEREOF PTPN6, PTPN1, PTPN11 PARP10 4534/4885PARP11 4154/4885NOTUM 3917/4885
US-20060178381-A1 Heterocyclic-substituted phenyl methanones CYP2B6, CYP2D6, CYP1A2 PARP10 2177/4885PARP11 2075/4885NOTUM 2424/4885
US-20260001865-A1 ANDROGEN RECEPTOR PROTACS AR, CRBN, PSMA3 PARP10 1055/4885PARP11 458/4885NOTUM 4532/4885
US-12590062-B2 PD-1/PD-L1 inhibitors CD274, PDCD1LG2, PDCD1 PARP10 2205/4885PARP11 599/4885NOTUM 4444/4885
US-12577231-B2 Androgen receptor PROTACS AR, CRBN, PSMA3 PARP10 1055/4885PARP11 458/4885NOTUM 4532/4885
US-20070287707-A1 Phosphodiesterase 10 inhibitors PDE7A, PDE7B, PDE10A PARP10 57/4885PARP11 709/4885NOTUM 161/4885
US-20070265258-A1 Quinazoline derivatives as phosphodiesterase 10 inhibitors PDE12, PDE5A, PDE7A PARP10 44/4885PARP11 895/4885NOTUM 446/4885
US-20080119422-A1 Indole Derivatives IDO1, TPH1, NAT1 PARP10 427/4885PARP11 452/4885NOTUM 4149/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.