Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 8/20 | 0.42 |
| ▸ | GRM5 | P41594 | 7/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.40 |
| ▸ | LIMK2 | P53671 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22777884 | 1.00 | SMARCA2 (0.43) | SMARCA2SMARCA4PBRM1GRM1GRM5 | |
| SCHEMBL25468683 | 0.87 | SMARCA2 (0.49) | SMARCA2SMARCA4PBRM1JAK1 | |
| SCHEMBL22777626 | 0.82 | SMARCA2 (0.54) | SMARCA2SMARCA4PBRM1JAK1BRD4 | |
| SCHEMBL22777343 | 0.81 | PDK4 (0.52) | SMARCA2SMARCA4PBRM1GRM1GRM5 | |
| SCHEMBL22777868 | 0.79 | SMARCA2 (0.48) | SMARCA2SMARCA4PBRM1JAK1 | |
| SCHEMBL22791037 | 0.74 | PBRM1 (0.40) | SMARCA2SMARCA4PBRM1 | |
| SCHEMBL30382571 | 0.72 | SMARCA2 (0.38) | SMARCA2SMARCA4PBRM1JAK1 | |
| SCHEMBL22777883 | 0.72 | SMARCA2 (0.38) | SMARCA2SMARCA4PBRM1JAK1 | |
| SCHEMBL24461134 | 0.72 | BRD4 (0.56) | SMARCA2SMARCA4PBRM1BRD4 | |
| SCHEMBL23580367 | 0.71 | NAMPT (0.47) | SMARCA2SMARCA4PBRM1GRM1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12521438-B2 | SMARCA degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2026-01-13 | — | — | US | disclosed |