Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.54 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.54 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22777868 | 0.91 | SMARCA2 (0.48) | SMARCA2SMARCA4PBRM1JAK2JAK1 | |
| SCHEMBL25468683 | 0.90 | SMARCA2 (0.49) | SMARCA2SMARCA4PBRM1JAK2JAK1 | |
| SCHEMBL24461134 | 0.86 | BRD4 (0.56) | SMARCA2SMARCA4PBRM1KDM4EHSD11B1 | |
| SCHEMBL24461244 | 0.83 | BRD4 (0.48) | SMARCA2SMARCA4PBRM1KDM4EHSD11B1 | |
| SCHEMBL29619410 | 0.83 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1JAK2JAK1 | |
| SCHEMBL29619399 | 0.83 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1JAK2JAK1 | |
| SCHEMBL24461790 | 0.83 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1JAK2JAK1 | |
| SCHEMBL24461526 | 0.83 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1JAK2JAK1 | |
| SCHEMBL20009090 | 0.82 | SMARCA2 (0.71) | SMARCA2SMARCA4PBRM1THRBSMN1; SMN2 | |
| SCHEMBL30606905 | 0.82 | SMARCA2 (0.71) | SMARCA2SMARCA4PBRM1THRBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220324880-A1 | SMARCA INHIBITORS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2022-10-13 | — | — | US | disclosed |
| WO-2020251974-A1 | SMARCA INHIBITORS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220324880-A1 | SMARCA INHIBITORS AND USES THEREOF | SMARCA1, SMARCE1, PBRM1 | SMARCA2 7/4885SMARCA4 8/4885PBRM1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.