Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.73 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | PPARA | Q07869 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7952282 | 0.88 | SIRT2 (0.72) | SIRT2HDAC1HDAC2HDAC8L3MBTL1 | |
| SCHEMBL13926724 | 0.88 | ACACB (0.65) | SIRT2HDAC1HDAC2HDAC8L3MBTL1 | |
| SCHEMBL7296066 | 0.84 | SIRT2 (0.75) | SIRT2HDAC1HDAC2HDAC8L3MBTL1 | |
| SCHEMBL27619410 | 0.83 | PPARA (0.59) | SIRT2HDAC1HDAC2HDAC8L3MBTL1 | |
| SCHEMBL3264894 | 0.83 | SPHK1 (0.67) | SIRT2L3MBTL1MAPTNPC1RAB9A | |
| SCHEMBL7148635 | 0.81 | SIRT2 (0.70) | SIRT2HDAC1HDAC2HDAC8L3MBTL1 | |
| SCHEMBL1312134 | 0.81 | SPHK1 (0.64) | SIRT2L3MBTL1NPC1RAB9AATM | |
| SCHEMBL1314770 | 0.81 | SPHK1 (0.64) | SIRT2L3MBTL1NPC1RAB9AATM | |
| SCHEMBL1311624 | 0.81 | SPHK1 (0.64) | SIRT2HDAC1HDAC2HDAC8L3MBTL1 | |
| SCHEMBL1312757 | 0.81 | SPHK1 (0.64) | SIRT2L3MBTL1NPC1RAB9AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010033701-A2 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION (US) | 2010-03-25 | — | — | WO | disclosed |