Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 13/20 | 0.40 |
| ▸ | MMP13 | P45452 | 8/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264181 | 0.83 | MMP12 (0.47) | MMP12MMP13 | |
| SCHEMBL3065992 | 0.80 | MMP12 (0.64) | MMP12MMP13 | |
| SCHEMBL3079850 | 0.80 | MMP12 (0.49) | MMP12MMP13 | |
| SCHEMBL3116953 | 0.80 | MMP12 (0.49) | MMP12MMP13 | |
| SCHEMBL3266042 | 0.79 | MMP12 (0.50) | MMP12MMP13 | |
| SCHEMBL8092743 | 0.76 | MMP12 (0.52) | MMP12MMP13ADAMTS4 | |
| SCHEMBL3077657 | 0.69 | MMP12 (0.66) | MMP12MMP13 | |
| SCHEMBL3077987 | 0.66 | MMP12 (0.62) | MMP12MMP13 | |
| SCHEMBL22780062 | 0.66 | CYP11B1 (0.51) | DYRK1APIK3CA | |
| SCHEMBL16923069 | 0.66 | CYP2A6 (0.52) | DYRK1APIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144893-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008137816-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH (US) | 2008-11-13 | — | — | WO | disclosed |