SCHEMBL32660745

SCHEMBL32660745

CC(C)(C)OC(=O)N1CCN(C(=O)NCc2ccc(C(F)(F)F)cc2)CC1

nearest known ligand 0.64

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.64
SMN1; SMN2 Q16637 3/20 0.55
MEN1 O00255 3/20 0.55
KMT2A Q03164 3/20 0.55
CYP2C19 P33261 1/20 0.55
HTT P42858 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54
LMNA P02545 1/20 0.53
GPR119 Q8TDV5 2/20 0.50
NPC1 O15118 1/20 0.49
TPSAB1 Q15661 3/20 0.49
TPSD1 Q9BZJ3 3/20 0.49
TPSG1 Q9NRR2 3/20 0.49
KIT P10721 1/20 0.47
TACR1 P25103 2/20 0.47
KCNH2 Q12809 1/20 0.47
HRH3 Q9Y5N1 1/20 0.47
PRSS1 P07477 2/20 0.46
F2 P00734 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15504601 0.88 TP53 (0.55) MAPTSMN1; SMN2MEN1KMT2ACYP2C19
SCHEMBL12801417 0.85 MEN1 (0.55) MAPTSMN1; SMN2MEN1KMT2ACYP2C19
SCHEMBL15515225 0.85 KDM4E (0.63) SMN1; SMN2MEN1KMT2ACYP2C19HTT
SCHEMBL31439466 0.84 MAPT (0.51) MAPTSMN1; SMN2MEN1KMT2ACYP2C19
SCHEMBL5464853 0.83 MEN1 (0.70) MEN1KMT2ANPC1TPSAB1KCNH2
SCHEMBL31716905 0.83 EPHX2 (0.62) MAPTGPR119NPC1TACR1
SCHEMBL1668815 0.82 SMN1; SMN2 (0.52) MAPTSMN1; SMN2MEN1KMT2ACYP2C19
SCHEMBL1943768 0.81 MAPT (0.93) MAPTMEN1KMT2AGPR119
SCHEMBL5546576 0.81 L3MBTL1 (0.62) MAPTGPR119
SCHEMBL27502582 0.81 HRH3 (0.62) MAPTSMN1; SMN2MEN1KMT2ACYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4678234-A1 ANTAGONIST HETEROCYCLIC COMPOUNDS INVOLVED IN THE CGAS-STING ROUTE Centre National de la Recherche Scientifique (FR) 2026-01-14 EP disclosed