Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL27641392 | 0.97 | PTGS1 (0.40) | PTGS1AKR1C3FFAR3LCKFYN | |
| Fluoride SCHEMBL27700715 | 0.97 | — | — | |
| SCHEMBL15042 | 0.93 | — | — | |
| SCHEMBL338643 | 0.93 | FFAR3 (0.43) | PTGS1AKR1C3FFAR3LCKFYN | |
| SCHEMBL8163204 | 0.93 | FFAR3 (0.43) | PTGS1AKR1C3FFAR3LCKFYN | |
| SCHEMBL18814 | 0.93 | — | — | |
| SCHEMBL1396002 | 0.93 | FFAR3 (0.43) | PTGS1AKR1C3FFAR3LCKFYN | |
| SCHEMBL871351 | 0.93 | FFAR3 (0.43) | PTGS1AKR1C3FFAR3LCKFYN | |
| SCHEMBL133954 | 0.93 | — | — | |
| Hydrochloric Acid SCHEMBL3838334 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100159281-A1 | MAGNETIC RECORDING MEDIUM MANUFACTURING METHOD | KABUSHIKI KAISHA TOSHIBA (JP) | 2010-06-24 | — | — | US | disclosed |