Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 1/20 | 0.48 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | KCNJ2 | P63252 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27544652 | 0.80 | CNR2 (0.53) | XIAPBIRC2CNR2SMN1; SMN2NOTUM | |
| SCHEMBL9393577 | 0.79 | CNR2 (0.52) | XIAPBIRC2CNR2SMN1; SMN2NOTUM | |
| SCHEMBL10241674 | 0.79 | NOTUM (0.66) | XIAPBIRC2CNR2SMN1; SMN2NOTUM | |
| SCHEMBL2087233 | 0.78 | SMN1; SMN2 (0.62) | KDM4ESMN1; SMN2NOTUMMAPK1ALDH1A1 | |
| SCHEMBL7830913 | 0.77 | CNR2 (0.47) | XIAPBIRC2CNR2KDM4ESMN1; SMN2 | |
| SCHEMBL3653813 | 0.76 | NOTUM (0.61) | XIAPBIRC2KDM4ESMN1; SMN2NOTUM | |
| SCHEMBL23207270 | 0.76 | XIAP (0.58) | XIAPBIRC2CNR2SMN1; SMN2NOTUM | |
| SCHEMBL8893534 | 0.76 | XIAP (0.58) | XIAPBIRC2CNR2NOTUMNPC1 | |
| SCHEMBL7552151 | 0.72 | NOTUM (0.63) | KDM4ESMN1; SMN2NOTUMLMNARAB9A | |
| SCHEMBL2530222 | 0.72 | CNR2 (0.62) | XIAPBIRC2CNR2NOTUMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740171-B1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-06-09 | — | — | EP | disclosed |