Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.46 |
| ▸ | CPT2 | P23786 | 1/20 | 0.45 |
| ▸ | CPT1A | P50416 | 1/20 | 0.45 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2530222 | 0.91 | CNR2 (0.62) | CNR2NOTUMHTR2AHTR2CXIAP | |
| SCHEMBL7552151 | 0.88 | NOTUM (0.63) | NOTUMHTR2AHTR2CSMN1; SMN2CYP3A4 | |
| SCHEMBL10241674 | 0.87 | NOTUM (0.66) | CNR2NOTUMHTR2AHTR2CXIAP | |
| SCHEMBL9393577 | 0.87 | CNR2 (0.52) | CNR2NOTUMHTR2AHTR2CXIAP | |
| SCHEMBL7382818 | 0.84 | NOTUM (0.62) | CNR2NOTUMHTR2AHTR2CCYP3A4 | |
| SCHEMBL28129591 | 0.83 | NOTUM (0.58) | NOTUMHTR2AHTR2CSMN1; SMN2CYP3A4 | |
| SCHEMBL7830913 | 0.81 | CNR2 (0.47) | CNR2NOTUMHTR2AHTR2CXIAP | |
| SCHEMBL3266400 | 0.80 | XIAP (0.48) | CNR2NOTUMHTR2AHTR2CXIAP | |
| SCHEMBL17785806 | 0.80 | ALDH1A1 (0.49) | NOTUMXIAPBRD4ATAD2SMN1; SMN2 | |
| SCHEMBL14403429 | 0.79 | CYP3A4 (0.43) | CNR2NOTUMHTR2AHTR2CXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1602191-A | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK AS (DK) | 2005-03-30 | — | — | CN | claimed |
| CN-1326519-C | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK AS (DK) | 2007-07-18 | — | — | CN | disclosed |
| CN-1602191-A | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK AS (DK) | 2005-03-30 | — | — | CN | disclosed |