Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 3/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3266552 | 0.89 | PPARD (0.50) | PPARDGRM5ESR2MMP2MMP9 | |
| SCHEMBL3267251 | 0.86 | PPARD (0.52) | PPARDKMT2APLAUTP53THRB | |
| SCHEMBL3267254 | 0.86 | PPARD (0.52) | PPARDKMT2APLAUTP53THRB | |
| SCHEMBL658722 | 0.84 | PPARD (0.77) | PPARD | |
| SCHEMBL658721 | 0.84 | PPARD (0.77) | PPARD | |
| SCHEMBL3266065 | 0.82 | PPARD (0.57) | PPARDMEN1KMT2ATP53MAPT | |
| SCHEMBL5959602 | 0.78 | PPARD (0.68) | PPARD | |
| SCHEMBL3270793 | 0.78 | PPARD (0.44) | PPARDMEN1KMT2ATP53THRB | |
| SCHEMBL3270787 | 0.78 | PPARD (0.44) | PPARDMEN1KMT2ATP53THRB | |
| SCHEMBL657036 | 0.77 | PPARD (0.66) | PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558571-B1 | NOVEL COMPOUNDS USEFUL IN TREATING PPAR MEDIATED DISEASES | HIGH POINT PHARMACEUTICALS LLC (US) | 2010-06-02 | — | — | EP | claimed |