Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3251118 | 1.00 | HRH3 (0.46) | HRH3KMT2ACHRM2CHRM1CHRM3 | |
| SCHEMBL3251113 | 1.00 | HRH3 (0.46) | HRH3KMT2ACHRM2CHRM1CHRM3 | |
| SCHEMBL3243609 | 1.00 | HRH3 (0.46) | HRH3KMT2ACHRM2CHRM1CHRM3 | |
| SCHEMBL3243608 | 1.00 | HRH3 (0.46) | HRH3KMT2ACHRM2CHRM1CHRM3 | |
| SCHEMBL3249504 | 0.88 | KDM4E (0.53) | HRH3KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL3249499 | 0.88 | KDM4E (0.53) | HRH3KMT2AKDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL1397993 | 0.82 | HRH3 (0.56) | HRH3KMT2AGPR119AKR1C3 | |
| SCHEMBL547046 | 0.82 | CHRM2 (0.50) | CHRM2CHRM1CHRM3GPR119KDM4E | |
| SCHEMBL547045 | 0.82 | CHRM2 (0.50) | CHRM2CHRM1CHRM3GPR119KDM4E | |
| SCHEMBL547468 | 0.80 | CHRM2 (0.48) | CHRM2CHRM1CHRM3GPR119KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118089-B1 | INDOL-2-YL-PIPERAZIN-1-YL-METHANONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-05-12 | — | — | EP | disclosed |