Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | PREP | P48147 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL547046 | 1.00 | CHRM2 (0.50) | CHRM2CHRM1CHRM3GPR119OPRK1 | |
| SCHEMBL547468 | 0.98 | CHRM2 (0.48) | CHRM2CHRM1CHRM3GPR119OPRK1 | |
| SCHEMBL20989256 | 0.90 | CHRM2 (0.55) | CHRM2CHRM1CHRM3GPR119ALDH1A1 | |
| SCHEMBL1091721 | 0.84 | CA12 (0.46) | CHRM2CHRM1CHRM3GPR119ALDH1A1 | |
| SCHEMBL4758033 | 0.84 | OPRK1 (0.46) | OPRK1KCNH2OPRM1KDM4E | |
| SCHEMBL4758034 | 0.84 | OPRK1 (0.46) | OPRK1KCNH2OPRM1KDM4E | |
| SCHEMBL1029432 | 0.83 | CHRM2 (0.47) | CHRM2CHRM1CHRM3GPR119OPRK1 | |
| SCHEMBL1029431 | 0.83 | CHRM2 (0.47) | CHRM2CHRM1CHRM3GPR119OPRK1 | |
| SCHEMBL14687597 | 0.83 | MAOB (0.43) | CHRM2CHRM1CHRM3GPR119ALDH1A1 | |
| SCHEMBL21526582 | 0.83 | CHRM2 (0.55) | CHRM2CHRM1CHRM3GPR119OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110586-B2 | 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors | NEUROSEARCH A/S (DK) | 2012-02-07 | — | — | US | disclosed |
| US-20100267764-A1 | 8-Aza-Bicyclo[3.2.1]Octane Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors | ANIONA APS (DK) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267764-A1 | 8-Aza-Bicyclo[3.2.1]Octane Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors | SLC18A2, SLC18A3, SLC6A2 | CHRM2 228/4885CHRM1 223/4885CHRM3 390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.