Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4243050 | 0.99 | SMN1; SMN2 (0.45) | SMN1; SMN2DPP4DPP8HTTKMT2A | |
| SCHEMBL3163086 | 0.93 | DPP4 (0.45) | SMN1; SMN2DPP4DPP8KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL4253272 | 0.92 | DPP4 (0.44) | SMN1; SMN2DPP4DPP8KMT2AMEN1 | |
| SCHEMBL3144868 | 0.89 | DPP4 (0.41) | SMN1; SMN2DPP4DPP8HTTKMT2A | |
| SCHEMBL3146940 | 0.87 | DPP4 (0.44) | SMN1; SMN2DPP4DPP8KMT2ANPSR1 | |
| SCHEMBL3162393 | 0.86 | ABCB1 (0.46) | SMN1; SMN2DPP4DPP8KMT2AMEN1 | |
| SCHEMBL3152625 | 0.86 | DPP4 (0.43) | SMN1; SMN2DPP4DPP8KMT2AMEN1 | |
| SCHEMBL3158190 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2HTTKMT2AGAANPSR1 | |
| SCHEMBL3149457 | 0.85 | KMT2A (0.45) | SMN1; SMN2DPP4DPP8HTTKMT2A | |
| Hydrochloric Acid SCHEMBL4247185 | 0.85 | DPP4 (0.42) | DPP4DPP8KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036892-B1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-03-10 | — | — | EP | disclosed |
| EP-2036892-A1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-03-18 | — | — | EP | disclosed |