Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4242672 | 0.99 | SMN1; SMN2 (0.45) | SMN1; SMN2CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL3155003 | 0.93 | CHRM2 (0.47) | SMN1; SMN2CHRM2HTR1ASLC6A4DRD3 | |
| Hydrochloric Acid SCHEMBL4253244 | 0.92 | CHRM2 (0.46) | SMN1; SMN2CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL3153786 | 0.87 | CHRM2 (0.48) | SMN1; SMN2CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL3163299 | 0.87 | CHRM2 (0.44) | SMN1; SMN2CHRM2HTR1ASLC6A4DRD3 | |
| Hydrochloric Acid SCHEMBL4242663 | 0.86 | CHRM2 (0.47) | SMN1; SMN2CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL3155094 | 0.86 | CHRM2 (0.47) | SMN1; SMN2CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL3267375 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AGAAHTTNPSR1 | |
| SCHEMBL3149553 | 0.85 | KMT2A (0.47) | SMN1; SMN2CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL3143069 | 0.85 | CHRM2 (0.46) | SMN1; SMN2CHRM2HTR1ASLC6A4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036892-B1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-03-10 | — | — | EP | disclosed |
| EP-2036892-A1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-03-18 | — | — | EP | disclosed |