SCHEMBL32675666

SCHEMBL32675666

COC(=O)c1ccc(Oc2ccc3cc(OCc4c(-c5c(Cl)cccc5Cl)noc4C4CC4)ccc3c2)nc1

nearest known ligand 0.59

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 20/20 0.59
HSD17B13 Q7Z5P4 1/20 0.57
FXR2 P51116 1/20 0.56
FABP1 P07148 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23474085 1.00 NR1H4 (0.59) NR1H4HSD17B13FXR2FABP1
SCHEMBL24313804 0.94 NR1H4 (0.55) NR1H4HSD17B13FXR2
SCHEMBL24313890 0.94 NR1H4 (0.55) NR1H4HSD17B13FXR2FABP1
SCHEMBL23474096 0.91 NR1H4 (0.69) NR1H4HSD17B13FXR2
SCHEMBL23474094 0.91 NR1H4 (0.54) NR1H4HSD17B13FXR2FABP1
SCHEMBL25209031 0.91 NR1H4 (0.68) NR1H4HSD17B13FXR2
SCHEMBL23474149 0.90 NR1H4 (0.51) NR1H4HSD17B13
SCHEMBL23474090 0.90 NR1H4 (0.53) NR1H4HSD17B13FXR2
SCHEMBL25206187 0.90 NR1H4 (0.60) NR1H4HSD17B13FXR2FABP1
SCHEMBL23474124 0.90 NR1H4 (0.67) NR1H4HSD17B13FXR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4073070-B1 COMPOUNDS FOR MODULATING ACTIVITY OF FXR AND USES THEREOF GANNEX PHARMA CO LTD (CN) 2026-02-18 EP disclosed