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SCHEMBL32675686

SCHEMBL32675686

CCc1cc(Nc2nccn3c(-c4ccc(OC)c(F)c4F)cnc23)ccc1C(=O)NCCCCC[N+](C)(C)CC(N)=O

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 6/20 0.33
▸ MAPKAPK5 Q8IW41 1/20 0.33
▸ PTK6 Q13882 1/20 0.32
▸ TTK P33981 3/20 0.31
▸ AXL P30530 1/20 0.31
▸ FGFR3 P22607 1/20 0.31
▸ ZAP70 P43403 1/20 0.30
▸ KARS1 Q15046 1/20 0.30
▸ PDE5A O76074 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25450841 1.00 SYK (0.33) SYKMAPKAPK5PTK6TTKAXL
Formic Acid SCHEMBL25167698 0.97 SYK (0.32) SYKMAPKAPK5PTK6AXL
SCHEMBL25450765 0.92 SYK (0.33) SYKMAPKAPK5PTK6TTKAXL
SCHEMBL25451055 0.90 PTK6 (0.32) SYKMAPKAPK5PTK6TTKAXL
SCHEMBL22123913 0.90 SYK (0.36) SYKMAPKAPK5PTK6TTKAXL
SCHEMBL22123726 0.90 SYK (0.36) SYKMAPKAPK5PTK6TTKAXL
SCHEMBL22123676 0.90 SYK (0.36) SYKMAPKAPK5PTK6TTKAXL
SCHEMBL22123449 0.90 SYK (0.36) SYKMAPKAPK5PTK6TTKAXL
Formic Acid SCHEMBL25170399 0.89 ADRA2B (0.32) SYKMAPKAPK5PTK6
SCHEMBL25450970 0.89 SYK (0.32) SYKMAPKAPK5PTK6TTKAXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4161931-B1 NOVEL IMIDAZOPYRAZINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2026-02-18 — — EP claimed
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