Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 4/20 | 0.49 |
| ▸ | CTSC | P53634 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 5/20 | 0.38 |
| ▸ | ACE | P12821 | 3/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | BMP1 | P13497 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205631 | 0.91 | GHSR (0.50) | GHSRCTSCMMP9MMP8CYP3A4 | |
| SCHEMBL6317001 | 0.89 | GHSR (0.48) | GHSRCTSCMMP9MMP8CYP3A4 | |
| SCHEMBL3266917 | 0.88 | GHSR (0.47) | GHSRCTSCMMP9MMP8CYP3A4 | |
| SCHEMBL3266844 | 0.86 | GHSR (0.48) | GHSRMMP9MMP8F2MME | |
| SCHEMBL3268315 | 0.85 | GHSR (0.45) | GHSRCTSCMMP9MMP8CYP3A4 | |
| SCHEMBL6326662 | 0.84 | GHSR (0.45) | GHSRCTSCMMP9MMP8CYP3A4 | |
| SCHEMBL8906086 | 0.81 | GHSR (0.43) | GHSRCTSCMMP9MMP8CYP3A4 | |
| SCHEMBL6324776 | 0.81 | GHSR (0.43) | GHSRCTSCMMP9MMP8CYP3A4 | |
| SCHEMBL3274994 | 0.81 | GHSR (0.51) | GHSRCTSCMMP9MMP8CYP3A4 | |
| SCHEMBL27506662 | 0.81 | GHSR (0.43) | GHSRCTSCMMP9MMP8CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047709-B1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2004-11-03 | — | — | EP | claimed |
| EP-1506969-B1 | Compounds with growth hormone releasing properties | HELSINN THERAPEUTICS US INC (US) | 2010-06-09 | — | — | EP | disclosed |
| EP-1506969-A1 | Compounds with growth hormone releasing properties | NOVO NORDISK A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| EP-1047709-B1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2004-11-03 | — | — | EP | disclosed |
| WO-1999036431-A9 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2000-07-27 | — | — | WO | disclosed |
| US-6083908-A | TREATING MEDICAL DISORDERS RESULTING FROM DEFICIENCY IN GROWTH HORMONE | NOVO NORDISK A/S (DK) | 2000-07-04 | — | — | US | disclosed |