SCHEMBL32680469

SCHEMBL32680469

Cc1ccc2c(c1C)C(=O)NC2=O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP2 O95551 1/20 0.56
NSD2 O96028 1/20 0.56
HSP90AA1 P07900 1/20 0.56
PAX8 Q06710 1/20 0.56
PARP1 P09874 5/20 0.47
PPOX P50336 1/20 0.42
GSK3B P49841 2/20 0.41
CDK4 P11802 1/20 0.40
CCNA2 P20248 1/20 0.40
CCND1 P24385 1/20 0.40
CDK2 P24941 1/20 0.40
CCNA1 P78396 1/20 0.40
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.40
GAA P10253 1/20 0.40
HPGD P15428 1/20 0.40
HSD17B10 Q99714 1/20 0.40
POLB P06746 1/20 0.38
WEE1 P30291 2/20 0.37
CHEK1 O14757 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10962827 1.00 TDP2 (0.56) TDP2NSD2HSP90AA1PAX8PARP1
Hydrochloric Acid SCHEMBL31218470 0.98 TDP2 (0.54) TDP2NSD2HSP90AA1PAX8PARP1
SCHEMBL5171611 0.79 PARP1 (0.46) TDP2NSD2HSP90AA1PAX8PARP1
SCHEMBL114048 0.79 PARP1 (0.46) TDP2NSD2HSP90AA1PAX8PARP1
SCHEMBL6154703 0.79 CES1 (0.55) PARP1PPOXGSK3BKDM4EALDH1A1
SCHEMBL10429595 0.79 WEE1 (0.42) PARP1PPOXGSK3BCDK4CCNA2
SCHEMBL30969378 0.79 PARP1 (0.46) TDP2NSD2HSP90AA1PAX8PARP1
SCHEMBL30884125 0.76 PARP1 (0.42) TDP2NSD2HSP90AA1PAX8PARP1
SCHEMBL20889634 0.76 PARP1 (0.40) TDP2NSD2HSP90AA1PAX8PARP1
SCHEMBL29212758 0.76 PARP1 (0.42) TDP2NSD2HSP90AA1PAX8PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4206205-B1 PREPARATION METHOD FOR PYRROLOPYRIMIDINE COMPOUND PRIMEGENE BEIJING CO LTD (CN) 2026-03-04 EP claimed