Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.77 |
| ▸ | ESR1 | P03372 | 1/20 | 0.75 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | MAOB | P27338 | 5/20 | 0.67 |
| ▸ | MAOA | P21397 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | RECQL | P46063 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.60 |
| ▸ | F3 | P13726 | 2/20 | 0.59 |
| ▸ | P4HB | P07237 | 1/20 | 0.58 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25200521 | 1.00 | CYP1B1 (0.77) | CYP1B1ESR1ESR2MAPTMAOB | |
| SCHEMBL3268064 | 1.00 | CYP1B1 (0.77) | CYP1B1ESR1ESR2MAPTMAOB | |
| SCHEMBL25212485 | 1.00 | CYP1B1 (0.77) | CYP1B1ESR1ESR2MAPTMAOB | |
| SCHEMBL1659833 | 0.93 | ESR1 (0.86) | CYP1B1ESR1ESR2MAPTMAOB | |
| SCHEMBL1659832 | 0.93 | ESR1 (0.86) | CYP1B1ESR1ESR2MAPTMAOB | |
| SCHEMBL25195374 | 0.89 | CYP1B1 (0.77) | CYP1B1ESR1ESR2MAPTMAOB | |
| SCHEMBL25203783 | 0.89 | CYP1B1 (0.77) | CYP1B1ESR1ESR2MAPTMAOB | |
| SCHEMBL25223617 | 0.89 | CYP1B1 (0.77) | CYP1B1ESR1ESR2MAPTMAOB | |
| SCHEMBL119183 | 0.89 | HCAR2 (0.65) | CYP1B1ESR1ESR2MAPTMAOB | |
| SCHEMBL4224730 | 0.89 | HCAR2 (0.65) | CYP1B1ESR1ESR2MAPTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101448802-B | Acrylamide derivative as histone deacetylase inhibitors for cancer treatment | DAC SRL | 2012-11-07 | — | — | CN | disclosed |
| US-8242175-B2 | Class of histone deacetylase inhibitors | DAC S.R.L. (IT) | 2012-08-14 | — | — | US | disclosed |
| EP-2049508-B1 | N-HYDROXY-3-(4-{3-PHENYL-3-OXO-PROPENYL}-PHENYL)-ACRYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF CANCER | DAC SRL (IT) | 2010-06-09 | — | — | EP | disclosed |
| US-20100113438-A1 | CLASS OF HISTONE DEACETYLASE INHIBITORS | DAC S.R.L. (IT) | 2010-05-06 | — | — | US | disclosed |
| CN-101448802-A | N-hydroxy-3-(4-{3-phenyl-S-oxo-propenyl}-phenyl)-acrylamide derivatives and related compounds as histone deacetylase inhibitors for the treatment of cancer | DAC SRL (IT) | 2009-06-03 | — | — | CN | disclosed |
| EP-2049508-A2 | N-HYDROXY-3-(4-{3-PHENYL-3-OXO-PROPENYL}-PHENYL)-ACRYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF CANCER | DAC S.r.l. (IT) | 2009-04-22 | — | — | EP | disclosed |
| WO-2007113249-A2 | N-HYDROXY-3-(4-{3-PHENYL-S-OXO-PROPENYL}-PHENYL)-ACRYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF CANCER | DAC S.R.L. (IT) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113438-A1 | CLASS OF HISTONE DEACETYLASE INHIBITORS | HDAC3, HDAC1, HDAC11 | CYP1B1 2427/4885ESR1 1469/4885ESR2 609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.