Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.52 |
| ▸ | DNM1 | Q05193 | 8/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 3/20 | 0.48 |
| ▸ | CES1 | P23141 | 3/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL829819 | 1.00 | LSS (0.52) | LSSDNM1HTTBBOX1CES2 | |
| Bicarbonate SCHEMBL28711949 | 1.00 | LSS (0.52) | LSSDNM1HTTBBOX1CES2 | |
| Bicarbonate SCHEMBL28426177 | 1.00 | LSS (0.52) | LSSDNM1HTTBBOX1CES2 | |
| Bicarbonate SCHEMBL8995828 | 0.98 | LSS (0.50) | LSSDNM1HTTBBOX1CES2 | |
| Oxalic Acid SCHEMBL7624948 | 0.93 | LSS (0.50) | LSSDNM1HTTBBOX1CES2 | |
| Acetic Acid SCHEMBL8378663 | 0.93 | LSS (0.50) | LSSDNM1HTTBBOX1CES2 | |
| Acetic Acid SCHEMBL5573581 | 0.93 | LSS (0.50) | LSSDNM1HTTBBOX1CES2 | |
| Acetic Acid SCHEMBL5574393 | 0.93 | LSS (0.50) | LSSDNM1HTTBBOX1CES2 | |
| Acetic Acid SCHEMBL11125571 | 0.93 | LSS (0.50) | LSSDNM1HTTBBOX1CES2 | |
| Bicarbonate SCHEMBL9763312 | 0.93 | LSS (0.50) | LSSDNM1HTTBBOX1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0963550-B1 | USE OF AN ION-SELECTIVE ELECTRODE AND METHOD FOR SELECTIVE DETERMINATION OF CARBON DIOXIDE IN BODY FLUIDS | KONELAB CORP (FI) | 2010-06-09 | — | — | EP | claimed |
| EP-0963550-A1 | ION-SELECTIVE ELECTRODE AND METHOD FOR SELECTIVE DETERMINATION OF ANALYTES IN BODY FLUIDS | Konelab Corporation (FI) | 1999-12-15 | — | — | EP | claimed |
| WO-1998038503-A1 | ION-SELECTIVE ELECTRODE AND METHOD FOR SELECTIVE DETERMINATION OF ANALYTES IN BODY FLUIDS | KONELAB CORPORATION (FI) | 1998-09-03 | — | — | WO | claimed |
| EP-0963550-B1 | USE OF AN ION-SELECTIVE ELECTRODE AND METHOD FOR SELECTIVE DETERMINATION OF CARBON DIOXIDE IN BODY FLUIDS | KONELAB CORP (FI) | 2010-06-09 | — | — | EP | disclosed |
| EP-1337507-A1 | CARBONATE IONOPHORE WITH IMPROVED SELECTIVITY FOR CARBONATE | DADE BEHRING INC. (US) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002042255-A1 | CARBONATE IONOPHORE WITH IMPROVED SELECTIVITY FOR CARBONATE | DADE BEHRING INC. (US) | 2002-05-30 | — | — | WO | disclosed |
| US-6391175-B1 | CARBONATES OR SALICYLATE COMPOUNDS AS IONOPHORS | DADE BEHRING INC. | 2002-05-21 | — | — | US | disclosed |
| EP-0963550-A1 | ION-SELECTIVE ELECTRODE AND METHOD FOR SELECTIVE DETERMINATION OF ANALYTES IN BODY FLUIDS | Konelab Corporation (FI) | 1999-12-15 | — | — | EP | disclosed |
| WO-1998038503-A1 | ION-SELECTIVE ELECTRODE AND METHOD FOR SELECTIVE DETERMINATION OF ANALYTES IN BODY FLUIDS | KONELAB CORPORATION (FI) | 1998-09-03 | — | — | WO | disclosed |
| EP-0358991-B2 | Test device for an optical determination of cations, anions or electrically neutral ionogenic species, and test method using said device | MOELLER WILLI AG (CH) | 1998-02-11 | — | — | EP | disclosed |
| EP-0281829-B1 | Adducts of ketonic compounds with the anions of oxygenated acids, process for their preparation, their use and azo ketonic compounds | MOELLER WILLI AG (CH) | 1994-05-04 | — | — | EP | disclosed |
| EP-0281829-A2 | Adducts of ketonic compounds with the anions of oxygenated acids, process for their preparation, their use and azo ketonic compounds | Willi Möller AG (CH) | 1988-09-14 | — | — | EP | disclosed |