Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.50 |
| ▸ | DNM1 | Q05193 | 8/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 3/20 | 0.46 |
| ▸ | CES1 | P23141 | 3/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7573774 | 1.00 | LSS (0.50) | LSSDNM1HTTBBOX1CES2 | |
| Bicarbonate SCHEMBL29180238 | 1.00 | LSS (0.50) | LSSDNM1HTTBBOX1CES2 | |
| Bicarbonate SCHEMBL829819 | 0.93 | LSS (0.52) | LSSDNM1HTTBBOX1CES2 | |
| Bicarbonate SCHEMBL28426177 | 0.93 | LSS (0.52) | LSSDNM1HTTBBOX1CES2 | |
| Bicarbonate SCHEMBL3268124 | 0.93 | LSS (0.52) | LSSDNM1HTTBBOX1CES2 | |
| Bicarbonate SCHEMBL28711949 | 0.93 | LSS (0.52) | LSSDNM1HTTBBOX1CES2 | |
| Oxalic Acid SCHEMBL7624961 | 0.91 | LSS (0.46) | LSSDNM1HTTBBOX1CES2 | |
| Bicarbonate SCHEMBL8995828 | 0.91 | LSS (0.50) | LSSDNM1HTTBBOX1CES2 | |
| Acetic Acid SCHEMBL2204892 | 0.91 | LSS (0.50) | LSSDNM1HTTBBOX1CES2 | |
| Acetic Acid SCHEMBL8378663 | 0.91 | LSS (0.50) | LSSDNM1HTTBBOX1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021528-A | Crosslinked bisphenol containing arylcyclobutene alkyl ethers and cured compositions therefrom | SHELL OIL COMPANY (US) | 1991-06-04 | — | — | US | disclosed |
| US-4943665-A | Modified bisphenols containing arylcyclobutenealkyl ethers and cured compositions therefrom | SHELL OIL COMPANY (US) | 1990-07-24 | — | — | US | disclosed |